Formularz CTCAE dla HL

Proszę wypełnić poniższy formularz w celu oceny działań niepożądanych.

🔽Morfologia Krwii

Zobacz wyniki w morfologii krwii

Anemia

KategoriaOpis
Grade 1 Hemoglobin (Hgb) < LLN - 10.0 g/dL; < LLN - 6.2 mmol/L; < LLN - 100 g/L
Grade 2 Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80 g/L
Grade 3 Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a reduction in the amount of hemoglobin...

Eosinophilia

KategoriaOpis
Grade 1 >ULN and >Baseline
Grade 2 -
Grade 3 Steroids initiated
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood.

Febrile neutropenia

KategoriaOpis
Grade 1 <1000/mms with a single temperature of 38.3°C
Grade 2 -
Grade 3 -
Grade 4 -
Grade 5 Life threatening consequences; Death
DefinitionA disorder characterized by a low neutrophil count (<1000/mms) with a single temperature of 38.3°C or higher.

Hemolysis

KategoriaOpis
Grade 1 Laboratory evidence of hemolysis
Grade 2 Evidence of hemolysis and 2 g/dL decrease in hemoglobin
Grade 3 Transfusion or medical intervention indicated (e.g., steroids)
Grade 4 -
Grade 5 Life threatening consequences; Death
DefinitionA disorder characterized by the destruction of red blood cells (hemolysis).

Leukocytosis

KategoriaOpis
Grade 1 -
Grade 2 -
Grade 3 >100,000/mm3
Grade 4 Clinical manifestations of leucostasis; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.

🔽EKG

Zobacz wyniki w EKG

Asystole

KategoriaOpis
Grade 1 Periods of asystole; non-urgent medical management indicated
Grade 2 -
Grade 3 -
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.

Atrial fibrillation

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation; new onset
Grade 4 Life-threatening consequences; embolus requiring urgent intervention
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles.

Atrial flutter

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation
Grade 4 Life-threatening consequences; embolus requiring urgent intervention
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria.

Atrioventricular block complete

KategoriaOpis
Grade 1 -
Grade 2 Non-urgent intervention indicated
Grade 3 Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.

Atrioventricular block first degree

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent intervention indicated
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.

Conduction disorder

KategoriaOpis
Grade 1 Mild symptoms; intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by pathological irregularities in the cardiac conduction system.

Mobitz (type) II atrioventricular block

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Symptomatic; medical intervention indicated
Grade 3 Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.

Mobitz type I

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Symptomatic; medical intervention indicated
Grade 3 Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.

Myocardial infarction

KategoriaOpis
Grade 1 -
Grade 2 Asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes
Grade 3 Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction
Grade 4 Life-threatening consequences; hemodynamically unstable
Grade 5 Death
DefinitionA disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.

Paroxysmal atrial tachycardia

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated; ablation
Grade 4 Life-threatening consequences; incompletely controlled medically; cardioversion indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.

Sick sinus syndrome

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Symptomatic, intervention not indicated; change in medication initiated
Grade 3 Symptomatic, intervention indicated
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.

Sinus bradycardia

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Symptomatic, intervention not indicated; change in medication initiated
Grade 3 Symptomatic, intervention indicated
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node.

Sinus tachycardia

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Symptomatic; non-urgent medical intervention indicated
Grade 3 Urgent medical intervention indicated
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.

Supraventricular tachycardia

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.

Ventricular arrhythmia

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Urgent intervention indicated
Grade 4 Life-threatening consequences; hemodynamic compromise
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia that originates in the ventricles.

Ventricular fibrillation

KategoriaOpis
Grade 1 -
Grade 2 -
Grade 3 -
Grade 4 Life-threatening consequences; hemodynamic compromise
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.

Ventricular tachycardia

KategoriaOpis
Grade 1 -
Grade 2 Non-urgent medical intervention indicated
Grade 3 Symptomatic, urgent intervention indicated
Grade 4 Life-threatening consequences; hemodynamic compromise
Grade 5 Death
DefinitionA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His.

Electrocardiogram QT corrected interval prolonged

KategoriaOpis
Grade 1 Average QTc 450 - 480 ms
Grade 2 Average QTc 481 - 500 ms
Grade 3 Average QTc >= 501 ms; >60 ms change from baseline
Grade 4 Torsade de pointes; polymorphic ventricular tachycardia; signs/symptoms of serious arrhythmia
Grade 5 -
DefinitionA finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.

Electrocardiogram T wave abnormal

KategoriaOpis
Grade 1 T wave flattening
Grade 2 Nonspecific ST segment change
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by Electrocardiogram T wave amplitude changes.

🔽Opieka pielęgniarska

Zobacz wyniki w sekcji pieki pielęgniarskiej

Fever

KategoriaOpis
Grade 1 38.0 - 39.0 degrees C (100.4 - 102.2 degrees F)
Grade 2 >39.0 - 40.0 degrees C (102.3 - 104.0 degrees F)
Grade 3 >40.0 degrees C (>104.0 degrees F) for <=24 hrs
Grade 4 >40.0 degrees C (>104.0 degrees F) for >24 hrs
Grade 5 Death
DefinitionA disorder characterized by elevation of the body's temperature above the upper limit of normal.

Hypothermia

Kategoria Opis
Grade 1 -
Grade 2 35 - >32 degrees C; 95 - >89.6 degrees F
Grade 3 32 - >28 degrees C; 89.6 - >82.4 degrees F
Grade 4 <=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)
Grade 5 Death
Definition A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.

Hypertension

KategoriaOpis
Grade 1 "Adult: Systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP ≥120/80 even if < 95th percentile"
Grade 2 "Adult: Systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130-139 or diastolic between 80-89 even if < 95th percentile"
Grade 3 "Adult: Systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; Pediatric and adolescent: Systolic and/or diastolic > 5 mmHg above the 99th percentile"
Grade 4 Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a pathological increase in blood pressure.

Hypotension

KategoriaOpis
Grade 1 Asymptomatic, intervention not indicated
Grade 2 Non-urgent medical intervention indicated
Grade 3 Medical intervention indicated; hospitalization indicated
Grade 4 Life-threatening consequences and urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.

Weight gain

KategoriaOpis
Grade 1 5 - <10% from baseline
Grade 2 10 - <20% from baseline
Grade 3 >=20% from baseline
Grade 4 -
Grade 5 -
DefinitionA finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve.

Weight loss

KategoriaOpis
Grade 1 5 to <10% from baseline; intervention not indicated
Grade 2 10 - <20% from baseline; nutritional support indicated
Grade 3 >=20% from baseline; tube feeding or TPN indicated
Grade 4 -
Grade 5 -
DefinitionA finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.

🔽Badanie ogólne moczu

Zobacz wyniki w badaniu ogólnym moczu

Acute kidney injury

KategoriaOpis
Grade 1 -
Grade 2 -
Grade 3 Hospitalization indicated
Grade 4 Life-threatening consequences; dialysis indicated
Grade 5 Death
DefinitionA disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).

Chronic kidney disease

KategoriaOpis
Grade 1 eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5
Grade 2 eGFR or CrCl 59 - 30 ml/min/1.73 m2
Grade 3 eGFR or CrCl 29 - 15 ml/min/1.73 m2
Grade 4 eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated
Grade 5 Death
DefinitionA disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.

Glucosuria

KategoriaOpis
Grade 1 Present
Grade 2 -
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by laboratory test results that indicate glucose in the urine.

Hematuria

KategoriaOpis
Grade 1 Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2 Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL
Grade 3 Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated; limiting self care ADL
Grade 4 Life-threatening consequences; urgent invasive intervention indicated
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate blood in the urine.

Hemoglobinuria

KategoriaOpis
Grade 1 Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2 -
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.

Proteinuria

KategoriaOpis
Grade 1 1+ proteinuria; urinary protein ≥ULN - <1.0 g/24 hrs
Grade 2 "Adult: 2+ and 3+ proteinuria; urinary protein 1.0 - <3.5 g/24 hrs; Pediatric: Urine P/C (Protein/Creatinine) ratio 0.5 - 1.9"
Grade 3 "Adult: Urinary protein >=3.5 g/24 hrs; 4+ proteinuria;Pediatric: Urine P/C (Protein/Creatinine) ratio >1.9"
Grade 4 -
Grade 5 -
DefinitionA disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.

🔽Morfologia Krwii

Zobacz wyniki w morfologii krwii

Hemoglobin increased

KategoriaOpis
Grade 1 Increase in >0 - 2 g/dL
Grade 2 Increase in >2 - 4 g/dL
Grade 3 Increase in >4 g/dL
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results that indicate increased levels of hemoglobin above normal.

Lymphocyte count decreased

KategoriaOpis
Grade 1 <LLN - 800/mm3; <LLN - 0.8 x 10e9/L
Grade 2 <800 - 500/mm3; <0.8 - 0.5 x 10e9 /L
Grade 3 <500 - 200/mm3; <0.5 - 0.2 x 10e9 /L
Grade 4 <200/mm3; <0.2 x 10e9 /L
Grade 5 -
DefinitionA finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.

Lymphocyte count increased

KategoriaOpis
Grade 1 -
Grade 2 >4000/mm3 - 20,000/mm3
Grade 3 >20,000/mm3
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.

Neutrophil count decreased

KategoriaOpis
Grade 1 <LLN - 1500/mm3; <LLN - 1.5 x 10e9 /L
Grade 2 <1500 - 1000/mm3; <1.5 - 1.0 x 10e9 /L
Grade 3 <1000 - 500/mm3; <1.0 - 0.5 x 10e9 /L
Grade 4 <500/mm3; <0.5 x 10e9 /L
Grade 5 -
DefinitionA finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.

Platelet count decreased

KategoriaOpis
Grade 1 <LLN - 75,000/mm3; <LLN - 75.0 x 10e9 /L
Grade 2 <75,000 - 50,000/mm3; <75.0 - 50.0 x 10e9 /L
Grade 3 <50,000 - 25,000/mm3; <50.0 - 25.0 x 10e9 /L
Grade 4 <25,000/mm3; <25.0 x 10e9 /L
Grade 5 -
DefinitionA finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.

White blood cell decreased

KategoriaOpis
Grade 1 <LLN - 3000/mm3; <LLN - 3.0 x 10e9 /L
Grade 2 <3000 - 2000/mm3; <3.0 - 2.0 x 10e9 /L
Grade 3 <2000 - 1000/mm3; <2.0 - 1.0 x 10e9 /L
Grade 4 <1000/mm3; <1.0 x 10e9 /L
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.

🔽Biochemia

Zobacz wyniki w badaniu biochemicznym

Hyperglycemia

KategoriaOpis
Grade 1 Abnormal glucose above baseline with no medical intervention
Grade 2 Change in daily management from baseline for a diabetic; oral antiglycemic agent initiated; workup for diabetes
Grade 3 Insulin therapy initiated; hospitalization indicated
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.

Hyperlipidemia

KategoriaOpis
Grade 1 Requiring diet changes
Grade 2 Requiring pharmaceutical intervention
Grade 3 Hospitalization; pancreatitis
Grade 4 Life-threatening consequences
Grade 5 -
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.

Hypertriglyceridemia

KategoriaOpis
Grade 1 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L
Grade 2 >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L
Grade 3 >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L
Grade 4 >1000 mg/dL; >11.4 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.

Hyperuricemia

KategoriaOpis
Grade 1 >ULN without physiologic consequences
Grade 2 -
Grade 3 >ULN with physiologic consequences
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.

Hypoalbuminemia

KategoriaOpis
Grade 1 <LLN - 3 g/dL; <LLN - 30 g/L
Grade 2 <3 - 2 g/dL; <30 - 20 g/L
Grade 3 <2 g/dL; <20 g/L
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.

Hypoglycemia

KategoriaOpis
Grade 1 <LLN - 55 mg/dL; <LLN - 3.0 mmol/L
Grade 2 <55 - 40 mg/dL; <3.0 - 2.2 mmol/L
Grade 3 <40 - 30 mg/dL; <2.2 - 1.7 mmol/L
Grade 4 <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.

Alanine aminotransferase increased

KategoriaOpis
Grade 1 >ULN - 3.0 x ULN if baseline was normal; 1.5 - 3.0 x baseline if baseline was abnormal
Grade 2 >3.0 - 5.0 x ULN if baseline was normal; >3.0 - 5.0 x baseline if baseline was abnormal
Grade 3 >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal
Grade 4 >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.

Alkaline phosphatase increased

KategoriaOpis
Grade 1 >ULN - 2.5 x ULN if baseline was normal; 2.0 - 2.5 x baseline if baseline was abnormal
Grade 2 >2.5 - 5.0 x ULN if baseline was normal; >2.5 - 5.0 x baseline if baseline was abnormal
Grade 3 >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal
Grade 4 >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.

Aspartate aminotransferase increased

KategoriaOpis
Grade 1 >ULN - 3.0 x ULN if baseline was normal; 1.5 - 3.0 x baseline if baseline was abnormal
Grade 2 >3.0 - 5.0 x ULN if baseline was normal; >3.0 - 5.0 x baseline if baseline was abnormal
Grade 3 >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal
Grade 4 >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.

Blood bilirubin increased

KategoriaOpis
Grade 1 >ULN - 1.5 x ULN if baseline was normal; > 1.0 - 1.5 x baseline if baseline was abnormal
Grade 2 >1.5 - 3.0 x ULN if baseline was normal; >1.5 - 3.0 x baseline if baseline was abnormal
Grade 3 >3.0 - 10.0 x ULN if baseline was normal; >3.0 - 10.0 x baseline if baseline was abnormal
Grade 4 >10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.

Blood lactate dehydrogenase increased

KategoriaOpis
Grade 1 >ULN
Grade 2 -
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results that indicate increased levels of lactate dehydrogenase in the blood specimen.

Cholesterol high

KategoriaOpis
Grade 1 >ULN - 300 mg/dL; >ULN - 7.75 mmol/L
Grade 2 >300 - 400 mg/dL; >7.75 - 10.34 mmol/L
Grade 3 >400 - 500 mg/dL; >10.34 - 12.92 mmol/L
Grade 4 >500 mg/dL; >12.92 mmol/L
Grade 5 -
DefinitionA finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.

CPK increased

KategoriaOpis
Grade 1 >ULN - 2.5 x ULN
Grade 2 >2.5 x ULN - 5 x ULN
Grade 3 >5 x ULN - 10 x ULN
Grade 4 >10 x ULN
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.

Creatinine increased

KategoriaOpis
Grade 1 >ULN - 1.5 x ULN
Grade 2 >1.5 - 3.0 x baseline; >1.5 - 3.0 x ULN
Grade 3 >3.0 x baseline; >3.0 - 6.0 x ULN
Grade 4 >6.0 x ULN
Grade 5 -
DefinitionA finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.

GGT increased

KategoriaOpis
Grade 1 >ULN - 2.5 x ULN if baseline was normal; 2.0 - 2.5 x baseline if baseline was abnormal
Grade 2 >2.5 - 5.0 x ULN if baseline was normal; >2.5 - 5.0 x baseline if baseline was abnormal
Grade 3 >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal
Grade 4 >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal
Grade 5 -
DefinitionA finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.

🔽Elektrolity

Zobacz wyniki w badaniu elektrolitów

Hypercalcemia

KategoriaOpis
Grade 1 Corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L
Grade 2 Corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic
Grade 3 Corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated
Grade 4 Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.

Hyperkalemia

KategoriaOpis
Grade 1 >ULN - 5.5 mmol/L
Grade 2 >5.5 - 6.0 mmol/L; intervention initiated
Grade 3 >6.0 - 7.0 mmol/L; hospitalization indicated
Grade 4 >7.0 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.

Hypermagnesemia

KategoriaOpis
Grade 1 >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L
Grade 2 -
Grade 3 >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L
Grade 4 >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.

Hypernatremia

KategoriaOpis
Grade 1 >ULN - 150 mmol/L
Grade 2 >150 - 155 mmol/L; intervention initiated
Grade 3 >155 - 160 mmol/L; hospitalization indicated
Grade 4 >160 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.

Hyperphosphatemia

KategoriaOpis
Grade 1 Laboratory finding only and intervention not indicated
Grade 2 Noninvasive intervention indicated
Grade 3 Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated
Grade 4 Life-threatening consequences; urgent intervention indicated (e.g., dialysis)
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate an elevation in the concentration of phosphate in a blood.

Hypocalcemia

KategoriaOpis
Grade 1 Corrected serum calcium of
Grade 2 Corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic
Grade 3 Corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated
Grade 4 Corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood.

Hypokalemia

KategoriaOpis
Grade 1 <LLN - 3.0 mmol/L
Grade 2 Symptomatic with <LLN - 3.0 mmol/L; intervention indicated
Grade 3 <3.0 - 2.5 mmol/L; hospitalization indicated
Grade 4 <2.5 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.

Hypomagnesemia

KategoriaOpis
Grade 1 <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L
Grade 2 <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L
Grade 3 <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L
Grade 4 <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.

Hyponatremia

KategoriaOpis
Grade 1 <LLN - 130 mmol/L
Grade 2 125-129 mmol/L and asymptomatic
Grade 3 125-129 mmol/L symptomatic; 120-124 mmol/L regardless of symptoms
Grade 4 <120 mmol/L; life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.

Hypophosphatemia

KategoriaOpis
Grade 1 Laboratory finding only and intervention not indicated
Grade 2 Oral replacement therapy indicated
Grade 3 Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.

🔽Krzepnięcie

Zobacz wyniki w badaniu elektrolitów

Activated partial thromboplastin time prolonged

KategoriaOpis
Grade 1 >ULN - 1.5 x ULN
Grade 2 >1.5 - 2.5 x ULN
Grade 3 >2.5 x ULN; bleeding
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.

Fibrinogen decreased

KategoriaOpis
Grade 1 <1.0 - 0.75 x LLN; if abnormal, <25% decrease from baseline
Grade 2 <0.75 - 0.5 x LLN; if abnormal, 25 - <50% decrease from baseline
Grade 3 <0.5 - 0.25 x LLN; if abnormal, 50 - <75% decrease from baseline
Grade 4 <0.25 x LLN; if abnormal, 75% decrease from baseline; absolute value <50 mg/dL
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.

INR increased

KategoriaOpis
Grade 1 >1.2 - 1.5; >1 - 1.5 x baseline if on anticoagulation; monitoring only indicated
Grade 2 >1.5 - 2.5; >1.5 - 2.5 x baseline if on anticoagulation; dose adjustment indicated
Grade 3 >2.5; >2.5 x baseline if on anticoagulation; bleeding
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.

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Haptoglobin decreased

KategoriaOpis
Grade 1 <LLN
Grade 2 -
Grade 3 -
Grade 4 -
Grade 5 -
DefinitionA finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.

Acidosis

KategoriaOpis
Grade 1 pH <normal, but >=7.3
Grade 2 -
Grade 3 pH <7.3
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.

Alkalosis

KategoriaOpis
Grade 1 pH >normal, but <=7.5
Grade 2 -
Grade 3 pH >7.5
Grade 4 Life-threatening consequences
Grade 5 Death
DefinitionA disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.

Tumor lysis syndrome

KategoriaOpis
Grade 1 -
Grade 2 -
Grade 3 Present
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death
DefinitionA disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells.

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